Structured Summary
Abstract
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
MeSH Record
Classification
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
See Also
MeSH Record
Synonyms
14 entry terms
- bcl-2 Proto-Oncogene Proteins
- c-bcl-2 Proteins
- Proto Oncogene Proteins c bcl 2
- Proto-Oncogene Proteins, bcl-2
- bcl 2 Proto Oncogene Proteins
- c bcl 2 Proteins
- c-bcl-2, Proto-Oncogene Proteins
- B-Cell Leukemia 2 Family Proteins
- BCL2 Family Proteins
- BCL2 Proteins
- B Cell Leukemia 2 Family Proteins
- Family Proteins, BCL2
- Proteins, BCL2
- Proteins, BCL2 Family
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
97; was PROTO-ONCOGENE PROTEIN BCL-2 (NM) 1989-96
MeSH Record
Previous Indexing
- Proto-Oncogene Proteins (1989-1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Proto-Oncogene Proteins c-bcl-2. Medical Subject Headings (MeSH). 2026. Unique ID D019253. http://id.nlm.nih.gov/mesh/2026/D019253
- Proto-Oncogene Proteins c-bcl-2. In: Wikipedia. https://en.wikipedia.org/wiki/Bcl-2_family
- Proto-Oncogene Proteins c-bcl-2. In: Wikidata. https://www.wikidata.org/wiki/Q554446