Chemicals and Drugs

Proto-Oncogene Proteins c-fos

Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.

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Synonyms

27 entry terms
  • Proto-Oncogene Products c-fos
  • Proto-Oncogene Proteins fos
  • c-fos Protein
  • c-fos Proteins
  • fos Proto-Oncogene Protein
  • fos Proto-Oncogene Proteins
  • p55 c-fos
  • p55(c-fos)
  • Protein, c-fos
  • Protein, fos Proto-Oncogene
  • Proto Oncogene Products c fos
  • Proto Oncogene Proteins c fos
  • Proto Oncogene Proteins fos
  • Proto-Oncogene Protein, fos
  • c fos Protein
  • c fos Proteins
  • fos Proto Oncogene Protein
  • fos Proto Oncogene Proteins
  • p55 c fos
  • Antigens, Fos-Related
  • FRAs
  • Fos B Protein
  • Fos-Related Antigen
  • Fos-Related Antigens
  • Antigen, Fos-Related
  • Fos Related Antigen
  • Fos Related Antigens

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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Indexing Annotation

/drug eff /ultrastruct permitted; not for c-fos 39 ( = C-FOS-ASSOCIATED PROTEIN P39 see PROTO-ONCOGENE PROTEINS C-JUN)

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History Note

92; was PROTO-ONCOGENE PROTEIN FOS (NM) 1985-91; FOS B PROTEIN was FOS B PROTEIN (NM) 1990-91

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Previous Indexing

  • Proto-Oncogene Proteins (1985-1991)

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Tree Numbers

  1. D12.776w.260w.108.765
  2. D12.776w.624.664.700.179
  3. D12.776w.660w.760
  4. D12.776w.930w.127.765

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins c-fos. Medical Subject Headings (MeSH). 2026. Unique ID D016760. http://id.nlm.nih.gov/mesh/2026/D016760
  2. Proto-Oncogene Proteins c-fos. In: Wikidata. https://www.wikidata.org/wiki/Q21149695