Chemicals and Drugs

Transcription Factor AP-1

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • AP-1
  • AP-1 Enhancer Binding Protein
  • AP-1 Enhancer-Binding Protein
  • Activator Protein-1
  • AP 1 Enhancer Binding Protein
  • Activator Protein 1
  • Enhancer-Binding Protein, AP-1
  • Transcription Factor AP 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

95; was TRANSCRIPTION FACTOR, AP-1 see PROTO-ONCOGENE PROTEINS C-JUN 1992-94; AP-1 ENHANCER-BINDING PROTEIN was see PROTO-ONCOGENE PROTEINS C-JUN 1992-94

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins c-jun (1992-1994)
  • Transcription Factors (1988-1994)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.108.875
  2. D12.776w.930w.127.875

AMA Style

References

  1. National Library of Medicine. Transcription Factor AP-1. Medical Subject Headings (MeSH). 2026. Unique ID D018808. http://id.nlm.nih.gov/mesh/2026/D018808
  2. Transcription Factor AP-1. In: Wikidata. https://www.wikidata.org/wiki/Q21116811