Chemicals and Drugs

Pyrimethamine

One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

Chemical Identity

Chemical Information

Molecular Formula
C12H13ClN4
Molecular Weight
248.71 g/mol
CAS Registry No.
58-14-0
IUPAC Name
5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
InChIKey
WKSAUQYGYAYLPV-UHFFFAOYSA-N
SMILES
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
MeSH Unique ID
D011739
Source
PubChem CID 4993

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Chloridin
  • Daraprim
  • Malocide
  • Tindurine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.383.742.675w

MeSH Record

NLM Classification

QV 256

AMA Style

References

  1. National Library of Medicine. Pyrimethamine. Medical Subject Headings (MeSH). 2026. Unique ID D011739. http://id.nlm.nih.gov/mesh/2026/D011739
  2. Pyrimethamine. In: Wikipedia. https://en.wikipedia.org/wiki/Pyrimethamine
  3. Pyrimethamine. In: Wikidata. https://www.wikidata.org/wiki/Q421072
  4. Pyrimethamine. In: PubChem Compound. CID 4993. https://pubchem.ncbi.nlm.nih.gov/compound/4993