Structured Summary
Abstract
Atypical gamma immunoglobulins characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive anaphylaxis and passive Arthus-type phenomena.
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
91(76); was see under PARAPROTEINS 1976-90
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Previous Indexing
- Heat (1972-1975)
- Immunoglobulins (1972-1975)
- Precipitation (1972-1975)
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References
- National Library of Medicine. Pyroglobulins. Medical Subject Headings (MeSH). 2026. Unique ID D011750. http://id.nlm.nih.gov/mesh/2026/D011750
- Pyroglobulins. In: Wikidata. https://www.wikidata.org/wiki/Q38083711