Structured Summary
Abstract
A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
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Classification
Broader headings
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Drug Class
Pharmacological Action
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Synonyms
3 entry terms
- RGS Protein (G-Protein Signaling)
- Regulators of G-Protein Signaling Proteins
- Regulators of G Protein Signaling Proteins
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
do not confuse with GTP-BINDING PROTEIN REGULATORS; not the same as RGS tripeptide
MeSH Record
History Note
2000; for RGS PROTEIN (G-PROTEIN SIGNALING) use GTPASE-ACTIVATING PROTEINS (NM) 1997-1999
MeSH Record
Previous Indexing
- Proteins (1989-1999)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. RGS Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D020710. http://id.nlm.nih.gov/mesh/2026/D020710
- RGS Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Regulator_of_G_protein_signaling
- RGS Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q6592084