Structured Summary
Abstract
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
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Synonyms
15 entry terms
- Gene Silencing, Post-Transcriptional
- Post-Transcriptional Gene Silencing
- Posttranscriptional Gene Silencing
- RNA Silencing
- RNAi
- Gene Silencing, Post Transcriptional
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
- Interference, RNA
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- Co-Suppression
- Cosuppression
- Co Suppression
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Aspects Covered
4 allowable subheadings
Indexed with the subheadings drug effects, immunology, physiology, radiation effects.
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History Note
2003
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NLM Classification
QU 58.7
AMA Style
References
- National Library of Medicine. RNA Interference. Medical Subject Headings (MeSH). 2026. Unique ID D034622. http://id.nlm.nih.gov/mesh/2026/D034622
- RNA Interference. In: Wikipedia. https://en.wikipedia.org/wiki/RNA_interference
- RNA Interference. In: Wikidata. https://www.wikidata.org/wiki/Q201993