Chemicals and Drugs

Receptor Activator of Nuclear Factor-kappa B

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

22 entry terms
  • CD265 Antigen
  • NF-Kappa B Receptor Activator
  • NF-KappaB Receptor Activator
  • RANK Protein
  • Receptor Activator of NF-kappa B
  • Receptor Activator of NF-kappaB
  • Receptor Activator of Nuclear Factor-kappaB
  • Receptors, Tumor Necrosis Factor, Member 11a
  • TNFRSF11A Protein
  • TRANCE Receptor
  • TRANCE-R
  • Tumor Necrosis Factor Receptor Superfamily, Member 11a
  • Activator, NF-KappaB Receptor
  • Antigen, CD265
  • NF Kappa B Receptor Activator
  • NF KappaB Receptor Activator
  • Receptor Activator of NF kappa B
  • Receptor Activator of NF kappaB
  • Receptor Activator of Nuclear Factor kappa B
  • Receptor Activator of Nuclear Factor kappaB
  • Receptor Activator, NF-KappaB
  • TRANCE R

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(1997)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.852w.760w.345w

AMA Style

References

  1. National Library of Medicine. Receptor Activator of Nuclear Factor-kappa B. Medical Subject Headings (MeSH). 2026. Unique ID D053246. http://id.nlm.nih.gov/mesh/2026/D053246
  2. Receptor Activator of Nuclear Factor-kappa B. In: Wikipedia. https://en.wikipedia.org/wiki/RANK
  3. Receptor Activator of Nuclear Factor-kappa B. In: Wikidata. https://www.wikidata.org/wiki/Q906651