Phenomena and Processes

Retinoblastoma Genes

Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.

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Broader headings

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Synonyms

7 entry terms
  • Genes, Rb
  • Genes, Retinoblastoma
  • Rb Genes
  • Gene, Rb
  • Gene, Retinoblastoma
  • Rb Gene
  • Retinoblastoma Gene

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

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History Note

91

MeSH Record

Previous Indexing

  • Retinoblastoma/genetics (1972-1990)

MeSH Hierarchy

Tree Numbers

  1. G05.360w.340w.024.340w.375.249w.400
  2. G05.360w.340w.024.340w.415.400w.400

MeSH Record

NLM Classification

QZ 210

AMA Style

References

  1. National Library of Medicine. Retinoblastoma Genes. Medical Subject Headings (MeSH). 2026. Unique ID D016161. http://id.nlm.nih.gov/mesh/2026/D016161
  2. Retinoblastoma Genes. In: Wikidata. https://www.wikidata.org/wiki/Q71151820