Chemicals and Drugs

Ritanserin

A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.

Chemical Identity

Chemical Information

Molecular Formula
C27H25F2N3OS
Molecular Weight
477.6 g/mol
CAS Registry No.
87051-43-2
IUPAC Name
6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
InChIKey
JUQLTPCYUFPYKE-UHFFFAOYSA-N
SMILES
CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3
MeSH Unique ID
D016713
Source
PubChem CID 5074

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 6-(2-(4-(Bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-a)pyrimidin-5-one
  • R-55667
  • Ritanserin Hydrochloride
  • Ritanserin Tartrate
  • R 55667
  • R55667

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was RITANSERIN (NM) 1985-91

MeSH Record

Previous Indexing

  • Histamine H2 Receptor Blockaders (1977-1991)
  • Piperidines (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.621.840w
  2. D03w.383.742.698.700w

AMA Style

References

  1. National Library of Medicine. Ritanserin. Medical Subject Headings (MeSH). 2026. Unique ID D016713. http://id.nlm.nih.gov/mesh/2026/D016713
  2. Ritanserin. In: Wikipedia. https://en.wikipedia.org/wiki/Ritanserin
  3. Ritanserin. In: Wikidata. https://www.wikidata.org/wiki/Q3937260
  4. Ritanserin. In: PubChem Compound. CID 5074. https://pubchem.ncbi.nlm.nih.gov/compound/5074