Chemicals and Drugs

SRS-A

A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a slow-reacting substance of ANAPHYLAXIS released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a slow-reacting substance of ANAPHYLAXIS released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)

MeSH Record

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Synonyms

1 entry terms
  • Slow Reacting Substance of Anaphylaxis

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

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Indexing Annotation

/biosyn /physiol permitted

MeSH Record

History Note

73(67)

MeSH Record

Previous Indexing

  • Anaphylaxis (1966)
  • Muscle, Smooth/physiology (1966)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.450w.855w
  2. D10w.251w.355w.310w.166.887w.855w
  3. D23.469.050w.175w.450w.725w

AMA Style

References

  1. National Library of Medicine. SRS-A. Medical Subject Headings (MeSH). 2026. Unique ID D013189. http://id.nlm.nih.gov/mesh/2026/D013189
  2. SRS-A. In: Wikipedia. https://en.wikipedia.org/wiki/Slow-reacting_substance_of_anaphylaxis
  3. SRS-A. In: Wikidata. https://www.wikidata.org/wiki/Q3268733