Structured Summary
Abstract
A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
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Synonyms
4 entry terms
- SIR Proteins, S cerevisiae
- Silent Information Regulator Proteins, S cerevisiae
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Silent Mating Type Information Regulator Protein, S cerevisiae
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30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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2003
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References
- National Library of Medicine. Saccharomyces cerevisiae Silent Information Regulator Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D038281. http://id.nlm.nih.gov/mesh/2026/D038281
- Saccharomyces cerevisiae Silent Information Regulator Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q78345181