Chemicals and Drugs

Sirtuins

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • SIRT
  • SIRTs
  • Silent Mating Type Information Regulator 2-like Proteins
  • Sir2-like Proteins
  • Sirtuin
  • Silent Mating Type Information Regulator 2 like Proteins
  • Sir2 like Proteins

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003

MeSH Record

Previous Indexing

  • Histone Deacetylase (2000-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.087w.520w.200.650
  2. D08.811w.913w.400w.725w.115.961
  3. D12.776w.476.900

AMA Style

References

  1. National Library of Medicine. Sirtuins. Medical Subject Headings (MeSH). 2026. Unique ID D037761. http://id.nlm.nih.gov/mesh/2026/D037761
  2. Sirtuins. In: Wikidata. https://www.wikidata.org/wiki/Q24782017