Chemicals and Drugs

Sirtuin 1

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • Silent Mating Type Information Regulation 2 Homolog 1
  • Sirt1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Histone Deacetylases (2002-2006)
  • Sirtuins (2007-2009)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.087w.520w.200.650.100w
  2. D12.776w.476.900.100w

AMA Style

References

  1. National Library of Medicine. Sirtuin 1. Medical Subject Headings (MeSH). 2026. Unique ID D056564. http://id.nlm.nih.gov/mesh/2026/D056564
  2. Sirtuin 1. In: Wikipedia. https://en.wikipedia.org/wiki/Sirtuin_1
  3. Sirtuin 1. In: Wikidata. https://www.wikidata.org/wiki/Q21113719