Chemicals and Drugs

Silybin

The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.

Chemical Identity

Chemical Information

Molecular Formula
C25H22O10
Molecular Weight
482.4 g/mol
CAS Registry No.
22888-70-6
IUPAC Name
(2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
InChIKey
SEBFKMXJBCUCAI-HKTJVKLFSA-N
SMILES
COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
MeSH Unique ID
D000077385
Source
PubChem CID 31553

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

25 entry terms
  • Silibin
  • Silibinin
  • Silybinin
  • 2,3-Dehydrosilybin
  • Alepa-forte
  • Ardeyhepan
  • Cefasilymarin
  • Durasilymarin
  • Hepa-Merz Sil
  • Hepa-loges
  • HepaBesch
  • Hepar-Pasc
  • Heparsyx
  • Heplant
  • Lagosa
  • Legalon Forte
  • Silibinin A
  • Silibinin B
  • Silybin A
  • Silybin B
  • 2,3 Dehydrosilybin
  • Alepa forte
  • Hepa Merz Sil
  • Hepa loges
  • Hepar Pasc

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2002)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.663.283.266.450w.268w.777.500w
  2. D03w.633.100.150.266.450w.268w.777.500w

AMA Style

References

  1. National Library of Medicine. Silybin. Medical Subject Headings (MeSH). 2026. Unique ID D000077385. http://id.nlm.nih.gov/mesh/2026/D000077385
  2. Silybin. In: Wikipedia. https://en.wikipedia.org/wiki/Silibinin
  3. Silybin. In: Wikidata. https://www.wikidata.org/wiki/Q425702
  4. Silybin. In: PubChem Compound. CID 31553. https://pubchem.ncbi.nlm.nih.gov/compound/31553