Chemicals and Drugs

Smoothened Receptor

A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Smoothened Protein
  • Smoothened Receptors
  • Receptor, Smoothened
  • Receptors, Smoothened

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Receptors, G-Protein-Coupled (2004-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.695w.017w.500
  2. D12.776w.543w.750w.850.500w.500

AMA Style

References

  1. National Library of Medicine. Smoothened Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D000072086. http://id.nlm.nih.gov/mesh/2026/D000072086
  2. Smoothened Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q3271551