Structured Summary
Abstract
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
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Synonyms
2 entry terms
- Specificity Protein 1 Transcription Factor
- Transcription Factor, Sp1
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
/drug eff /ultrastruct permitted; in titles & translations use SP1 (the figure one), not SPl (the letter l)
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History Note
2006(1991)
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Previous Indexing
- DNA-Binding Proteins (1986-1990)
- Transcription Factors (1986-1990)
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AMA Style
References
- National Library of Medicine. Sp1 Transcription Factor. Medical Subject Headings (MeSH). 2026. Unique ID D016329. http://id.nlm.nih.gov/mesh/2026/D016329
- Sp1 Transcription Factor. In: Wikidata. https://www.wikidata.org/wiki/Q4049840