Phenomena and Processes

HIV Long Terminal Repeat

Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.

MeSH Record

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Synonyms

27 entry terms
  • Human Immunodeficiency Virus LTR
  • Human Immunodeficiency Virus Long Terminal Repeat
  • LTR, Human Immunodeficiency Virus
  • Long Terminal Repeat, HIV
  • HIV Negative Regulatory Element
  • HIV Sp1-Binding Site
  • HIV Trans-Acting Responsive Region
  • HIV-1 LTR
  • Negative Regulatory Element, HIV
  • Sp1-Binding Site, HIV
  • TAR Element, HIV
  • Trans-Acting Responsive Region, HIV
  • Trans-Activation Responsive Element, HIV
  • Trans-Activation Responsive Region, HIV
  • HIV 1 LTR
  • HIV Sp1 Binding Site
  • HIV Sp1-Binding Sites
  • HIV TAR Element
  • HIV TAR Elements
  • HIV Trans Acting Responsive Region
  • LTR, HIV-1
  • Sp1 Binding Site, HIV
  • Sp1-Binding Sites, HIV
  • TAR Elements, HIV
  • Trans Acting Responsive Region, HIV
  • Trans Activation Responsive Element, HIV
  • Trans Activation Responsive Region, HIV

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Repetitive Sequences, Nucleic Acid (1986-1990)

MeSH Hierarchy

Tree Numbers

  1. G02.111.570.080w.708w.850.400
  2. G05.360w.080w.708w.850.400

AMA Style

References

  1. National Library of Medicine. HIV Long Terminal Repeat. Medical Subject Headings (MeSH). 2026. Unique ID D016325. http://id.nlm.nih.gov/mesh/2026/D016325
  2. HIV Long Terminal Repeat. In: Wikidata. https://www.wikidata.org/wiki/Q71158772