Chemicals and Drugs

Spastin

An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

1 entry terms
  • Spastic Paraplegia 4 Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Adenosine Triphosphatases (1999-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.013w.500.500
  2. D08.811w.277w.040w.025w.024.500
  3. D12.776w.157w.025w.750.500
  4. D12.776w.220.600.450w.465
  5. D12.776w.631w.560w.480

AMA Style

References

  1. National Library of Medicine. Spastin. Medical Subject Headings (MeSH). 2026. Unique ID D000074181. http://id.nlm.nih.gov/mesh/2026/D000074181
  2. Spastin. In: Wikidata. https://www.wikidata.org/wiki/Q24779266