Chemicals and Drugs

Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

28 entry terms
  • CYP51 Cytochrome P-450
  • Cytochrome P-450 CYP51
  • Eburicol 14 alpha-Demethylase
  • Eburicol 14alpha-Demethylase
  • Lanosterol 14 alpha-Demethylase
  • Obtusifoliol 14alpha-Demethylase
  • Sterol 14-Demethylases
  • Sterol 14-alpha-Demethylase
  • 14 alpha-Demethylase, Eburicol
  • 14 alpha-Demethylase, Lanosterol
  • 14-Demethylase, Sterol
  • 14-Demethylases, Sterol
  • 14-alpha-Demethylase, Sterol
  • 14alpha-Demethylase, Eburicol
  • 14alpha-Demethylase, Obtusifoliol
  • CYP51 Cytochrome P 450
  • CYP51, Cytochrome P-450
  • Cytochrome P 450 CYP51
  • Cytochrome P-450, CYP51
  • Eburicol 14 alpha Demethylase
  • Eburicol 14alpha Demethylase
  • Lanosterol 14 alpha Demethylase
  • Obtusifoliol 14alpha Demethylase
  • P-450 CYP51, Cytochrome
  • P-450, CYP51 Cytochrome
  • Sterol 14 Demethylase
  • Sterol 14 Demethylases
  • Sterol 14 alpha Demethylase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2011

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.878.500w
  2. D08.244w.453w.915w.880w
  3. D08.811w.682w.690w.708.170w.499.500w
  4. D08.811w.682w.690w.708.170w.915w.880w
  5. D12.776w.422w.220w.453w.878.500w
  6. D12.776w.422w.220w.453w.915w.880w

AMA Style

References

  1. National Library of Medicine. Sterol 14-Demethylase. Medical Subject Headings (MeSH). 2026. Unique ID D058886. http://id.nlm.nih.gov/mesh/2026/D058886
  2. Sterol 14-Demethylase. In: Wikipedia. https://en.wikipedia.org/wiki/Sterol_14-demethylase
  3. Sterol 14-Demethylase. In: Wikidata. https://www.wikidata.org/wiki/Q1805541