Structured Summary
Abstract
Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
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8 entry terms
- a-Synucleinopathies
- alpha Synuclein Pathology
- alpha-Synucleinopathies
- Synucleinopathy
- a-Synucleinopathy
- alpha Synuclein Pathologies
- alpha Synucleinopathies
- alpha-Synucleinopathy
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35 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
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History Note
2020
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Previous Indexing
- Neurodegenerative Diseases (1998-2019)
- alpha-Synuclein (1999-2019)
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References
- National Library of Medicine. Synucleinopathies. Medical Subject Headings (MeSH). 2026. Unique ID D000080874. http://id.nlm.nih.gov/mesh/2026/D000080874
- Synucleinopathies. In: Wikipedia. https://en.wikipedia.org/wiki/Synucleinopathy
- Synucleinopathies. In: Wikidata. https://www.wikidata.org/wiki/Q2376264