Chemicals and Drugs

TRPP Cation Channels

A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • Polycystin
  • Polycystins
  • Cation Channels, TRPP
  • Channels, TRPP Cation
  • Autosomal Dominant Polycystic Kidney Disease Type II Protein
  • PKD1 Protein
  • PKD2 Protein
  • Polycystic Breakpoint (PBP) Protein
  • Polycystic Kidney Disease 1 Protein
  • Polycystic Kidney Disease 2 Protein
  • Polycystin 1
  • Polycystin 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2026 (2006)

MeSH Record

Previous Indexing

  • Polycystic Kidney Diseases (1995-2005)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.150w.900w
  2. D12.776w.157w.530w.400w.901w.777w
  3. D12.776w.543w.585w.400w.150w.900w
  4. D12.776w.543w.585w.400w.901w.777w

AMA Style

References

  1. National Library of Medicine. TRPP Cation Channels. Medical Subject Headings (MeSH). 2026. Unique ID D050396. http://id.nlm.nih.gov/mesh/2026/D050396
  2. TRPP Cation Channels. In: Wikipedia. https://en.wikipedia.org/wiki/TRPP
  3. TRPP Cation Channels. In: Wikidata. https://www.wikidata.org/wiki/Q7671486