Chemicals and Drugs

Transient Receptor Potential Channels

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

12 entry terms
  • TRP Cation Channel
  • TRP Cation Channels
  • TRP Membrane Proteins
  • Transient Receptor Potential Cation Channel
  • Transient Receptor Potential Cation Channels
  • Transient Receptor Potential Channel
  • Cation Channel, TRP
  • Cation Channels, TRP
  • Channel, TRP Cation
  • Channels, TRP Cation
  • Membrane Proteins, TRP
  • Proteins, TRP Membrane

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN

MeSH Record

History Note

2006

MeSH Record

Previous Indexing

  • Calcium Channels (1989-2005)
  • Ion Channels (1995-2005)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.901w
  2. D12.776w.543w.585w.400w.901w

AMA Style

References

  1. National Library of Medicine. Transient Receptor Potential Channels. Medical Subject Headings (MeSH). 2026. Unique ID D050051. http://id.nlm.nih.gov/mesh/2026/D050051
  2. Transient Receptor Potential Channels. In: Wikipedia. https://en.wikipedia.org/wiki/Transient_receptor_potential_channel
  3. Transient Receptor Potential Channels. In: Wikidata. https://www.wikidata.org/wiki/Q304043