Chemicals and Drugs

Triggering Receptor Expressed on Myeloid Cells-1

An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • CD354 Antigen
  • TREM-1 Protein
  • Antigen, CD354
  • TREM 1 Protein
  • Triggering Receptor Expressed on Myeloid Cells 1

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Membrane Glycoproteins (2000-2017)
  • Receptors, Immunologic (2000-2017)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.919
  2. D12.776w.395w.550w.919
  3. D12.776w.543w.550w.919
  4. D12.776w.543w.750w.705w.985

AMA Style

References

  1. National Library of Medicine. Triggering Receptor Expressed on Myeloid Cells-1. Medical Subject Headings (MeSH). 2026. Unique ID D000073871. http://id.nlm.nih.gov/mesh/2026/D000073871
  2. Triggering Receptor Expressed on Myeloid Cells-1. In: Wikidata. https://www.wikidata.org/wiki/Q59250667