Chemicals and Drugs

Trihexyphenidyl

One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

Chemical Identity

Chemical Information

Molecular Formula
C20H31NO
Molecular Weight
301.5 g/mol
CAS Registry No.
144-11-6
IUPAC Name
1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
InChIKey
HWHLPVGTWGOCJO-UHFFFAOYSA-N
SMILES
C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
MeSH Unique ID
D014282
Source
PubChem CID 5572

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • Benzhexol
  • Apo-Trihex
  • Artane
  • Cyclodol
  • Hipokinon
  • Parkinane
  • Parkopan
  • Trihexane
  • Trihexidyl Hydrochloride
  • Trihexyphenidyl Hydrochloride
  • Trihexyphenidyl Hydrochloride Elixir
  • Apo Trihex
  • ApoTrihex

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Trihexyphenidyl. Medical Subject Headings (MeSH). 2026. Unique ID D014282. http://id.nlm.nih.gov/mesh/2026/D014282
  2. Trihexyphenidyl. In: Wikipedia. https://en.wikipedia.org/wiki/Trihexyphenidyl
  3. Trihexyphenidyl. In: Wikidata. https://www.wikidata.org/wiki/Q2991856
  4. Trihexyphenidyl. In: PubChem Compound. CID 5572. https://pubchem.ncbi.nlm.nih.gov/compound/5572