Chemicals and Drugs

Trimethaphan

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

Chemical Identity

Chemical Information

Molecular Formula
C22H25N2OS+
Molecular Weight
365.5 g/mol
CAS Registry No.
7187-66-8
IUPAC Name
3,5-dibenzyl-8-thionia-3,5-diazatricyclo[6.3.0.02,6]undecan-4-one
InChIKey
CHQOEHPMXSHGCL-UHFFFAOYSA-N
SMILES
C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
MeSH Unique ID
D014294
Source
PubChem CID 23576

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Thimethaphan
  • Trimetaphan

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.383.129w.308.935

AMA Style

References

  1. National Library of Medicine. Trimethaphan. Medical Subject Headings (MeSH). 2026. Unique ID D014294. http://id.nlm.nih.gov/mesh/2026/D014294
  2. Trimethaphan. In: Wikidata. https://www.wikidata.org/wiki/Q9361596
  3. Trimethaphan. In: PubChem Compound. CID 23576. https://pubchem.ncbi.nlm.nih.gov/compound/23576