Chemicals and Drugs

Trimetrexate

A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Chemical Identity

Chemical Information

Molecular Formula
C19H23N5O3
Molecular Weight
369.4 g/mol
CAS Registry No.
52128-35-5
IUPAC Name
5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine
InChIKey
NOYPYLRCIDNJJB-UHFFFAOYSA-N
SMILES
CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC
MeSH Unique ID
D016597
Source
PubChem CID 5583

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • CI-898
  • JB-11
  • NSC-249008
  • NSC-328564
  • Trimetrexate Hydrate
  • Trimetrexate Monohydrate, Monoacetate
  • CI 898
  • CI898
  • Hydrate, Trimetrexate
  • JB 11
  • JB11
  • Monohydrate, Monoacetate Trimetrexate
  • NSC 249008
  • NSC 328564
  • NSC249008
  • NSC328564

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was TRIMETREXATE (NM) 1979-91

MeSH Record

Previous Indexing

  • Antineoplastic Agents (1966-1991)
  • Folic Acid Antagonists (1966-1991)
  • Quinazolines (1966-1991)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.786.925w

AMA Style

References

  1. National Library of Medicine. Trimetrexate. Medical Subject Headings (MeSH). 2026. Unique ID D016597. http://id.nlm.nih.gov/mesh/2026/D016597
  2. Trimetrexate. In: Wikipedia. https://en.wikipedia.org/wiki/Trimetrexate
  3. Trimetrexate. In: Wikidata. https://www.wikidata.org/wiki/Q126677485
  4. Trimetrexate. In: PubChem Compound. CID 5583. https://pubchem.ncbi.nlm.nih.gov/compound/5583