Phenomena and Processes

Trinucleotide Repeat Expansion

An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • Expanded Trinucleotide Repeat
  • Expanded Trinucleotide Repeats
  • Expansion, Trinucleotide Repeat
  • Expansions, Trinucleotide Repeat
  • Repeat Expansion, Trinucleotide
  • Repeat Expansions, Trinucleotide
  • Repeat, Expanded Trinucleotide
  • Repeats, Expanded Trinucleotide
  • Trinucleotide Repeat Expansions
  • Trinucleotide Repeat, Expanded
  • Trinucleotide Repeats, Expanded

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

99(98)

MeSH Record

Previous Indexing

  • Repetitive Sequences, Nucleic Acid (1981-1997)

MeSH Hierarchy

Tree Numbers

  1. G02.111.570.080w.708w.800w.140.865w
  2. G02.111.570.080w.708w.800w.500w.850.200w
  3. G05.360w.080w.708w.800w.074.865w
  4. G05.360w.080w.708w.800w.500w.850.200w
  5. G05.360w.340w.024.189w.220.865w
  6. G05.360w.340w.024.850w.500w.850.200w
  7. G05.365w.590w.220.865w
  8. G05.558w.220.865w

AMA Style

References

  1. National Library of Medicine. Trinucleotide Repeat Expansion. Medical Subject Headings (MeSH). 2026. Unique ID D019680. http://id.nlm.nih.gov/mesh/2026/D019680
  2. Trinucleotide Repeat Expansion. In: Wikipedia. https://en.wikipedia.org/wiki/Trinucleotide_repeat_expansion
  3. Trinucleotide Repeat Expansion. In: Wikidata. https://www.wikidata.org/wiki/Q6736610