Structured Summary
Abstract
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
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Broader headings
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Synonyms
9 entry terms
- Cachectin
- Cachectin-Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNF-alpha
- TNFalpha
- Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor alpha
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2005(1988)
MeSH Record
Previous Indexing
- Endotoxins (1975-1987)
- Glycoproteins (1975-1987)
- Necrosis (1975-1987)
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AMA Style
References
- National Library of Medicine. Tumor Necrosis Factor-alpha. Medical Subject Headings (MeSH). 2026. Unique ID D014409. http://id.nlm.nih.gov/mesh/2026/D014409
- Tumor Necrosis Factor-alpha. In: Wikidata. https://www.wikidata.org/wiki/Q24788449