Chemicals and Drugs

Type I Site-Specific Deoxyribonucleases

Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.

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Synonyms

14 entry terms
  • DNA Restriction Enzymes, Type I
  • DNase, Site Specific, Type I
  • DNase, Site-Specific, Type I
  • Deoxyribonucleases, Type I Site-Specific
  • Deoxyribonucleases, Type I, Site Specific
  • Deoxyribonucleases, Type I, Site-Specific
  • Restriction Endonucleases, Type I
  • Site-Specific DNase, Type I
  • Type I Restriction Enzymes
  • Type I Site Specific DNase
  • Type I Site Specific Deoxyribonucleases
  • Type I Site-Specific DNase
  • Deoxyribonucleases, Type I Site Specific
  • Site Specific DNase, Type I

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • DNA Restriction Enzymes (1978-1988)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.150w.280w.250w
  2. D08.811w.277w.352w.335w.350w.300w.250w
  3. D08.811w.277w.352w.355w.325w.300w.250w

AMA Style

References

  1. National Library of Medicine. Type I Site-Specific Deoxyribonucleases. Medical Subject Headings (MeSH). 2026. Unique ID D015253. http://id.nlm.nih.gov/mesh/2026/D015253
  2. Type I Site-Specific Deoxyribonucleases. In: Wikipedia. https://en.wikipedia.org/wiki/Type_I_site-specific_deoxyribonuclease
  3. Type I Site-Specific Deoxyribonucleases. In: Wikidata. https://www.wikidata.org/wiki/Q22326532