Chemicals and Drugs

Vascular Endothelial Growth Factor Receptor-2

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

16 entry terms
  • Fetal Liver Kinase-1
  • Flk-1 Protein
  • Flk-1 Receptor Tyrosine Kinase
  • KDR Tyrosine Kinase
  • Kinase Insert Domain Receptor
  • VEGF Receptor Flk-1
  • VEGF Receptor KDR
  • VEGFR-2
  • Fetal Liver Kinase 1
  • Flk 1 Protein
  • Flk 1 Receptor Tyrosine Kinase
  • Flk-1, VEGF Receptor
  • KDR, VEGF Receptor
  • Tyrosine Kinase, KDR
  • VEGF Receptor Flk 1
  • Vascular Endothelial Growth Factor Receptor 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for FETAL LIVER KINASE-1, KDR TYROSINE KINASE, FLK-1 RECEPTOR TYROSINE KINASE & FLK-1 PROTEIN use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR 1993-2002; for VEGFR-2 use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR 1996-2002

MeSH Record

Previous Indexing

  • Protein-Tyrosine Kinase (1993)
  • Receptor Protein-Tyrosine Kinases (1994-2002)
  • Receptors, Growth Factor (1993-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.950w.200
  2. D12.776w.476.568w.400w.950w.200
  3. D12.776w.543w.750w.630w.750w.200
  4. D12.776w.543w.750w.750w.400w.910w.200

AMA Style

References

  1. National Library of Medicine. Vascular Endothelial Growth Factor Receptor-2. Medical Subject Headings (MeSH). 2026. Unique ID D040301. http://id.nlm.nih.gov/mesh/2026/D040301
  2. Vascular Endothelial Growth Factor Receptor-2. In: Wikidata. https://www.wikidata.org/wiki/Q24773561