Chemicals and Drugs

Voltage-Gated Sodium Channel beta-1 Subunit

A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • SCN1B Sodium Channel beta Subunit
  • Voltage Gated Sodium Channel beta 1 Subunit

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2013

MeSH Record

Previous Indexing

  • Sodium Channels (2002-2012)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.875w.750.960.100
  2. D12.776w.543w.550w.450w.875w.750.970.100
  3. D12.776w.543w.585w.400w.875w.750.970.100
  4. D12.776w.631w.960.970.100

AMA Style

References

  1. National Library of Medicine. Voltage-Gated Sodium Channel beta-1 Subunit. Medical Subject Headings (MeSH). 2026. Unique ID D062547. http://id.nlm.nih.gov/mesh/2026/D062547
  2. Voltage-Gated Sodium Channel beta-1 Subunit. In: Wikidata. https://www.wikidata.org/wiki/Q21135442