Chemicals and Drugs

Vorinostat

A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.

Chemical Identity

Chemical Information

Molecular Formula
C14H20N2O3
Molecular Weight
264.32 g/mol
CAS Registry No.
149647-78-9
IUPAC Name
N'-hydroxy-N-phenyloctanediamide
InChIKey
WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
MeSH Unique ID
D000077337
Source
PubChem CID 5311

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • N-Hydroxy-N'-phenyloctanediamide
  • N1-Hydroxy-N8-phenyloctanediamide
  • NHNPODA
  • Suberanilohydroxamic Acid
  • Suberoyl Anilide Hydroxamic Acid
  • Suberoylanilide Hydroxamic Acid
  • N Hydroxy N' phenyloctanediamide
  • N1 Hydroxy N8 phenyloctanediamide
  • 18F-SAHA
  • 18F-Suberoylanilide Hydroxamic Acid
  • M344
  • MK-0683
  • MK0683
  • Zolinza
  • 18F Suberoylanilide Hydroxamic Acid
  • MK 0683

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1998)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.199w.960w
  2. D02w.092w.146.113w.960w
  3. D02w.092w.570.394w.690w
  4. D02w.241w.511w.372w.690w

AMA Style

References

  1. National Library of Medicine. Vorinostat. Medical Subject Headings (MeSH). 2026. Unique ID D000077337. http://id.nlm.nih.gov/mesh/2026/D000077337
  2. Vorinostat. In: Wikipedia. https://en.wikipedia.org/wiki/Vorinostat
  3. Vorinostat. In: Wikidata. https://www.wikidata.org/wiki/Q905901
  4. Vorinostat. In: PubChem Compound. CID 5311. https://pubchem.ncbi.nlm.nih.gov/compound/5311