Structured Summary
Abstract
A Wnt protein and ligand for FRIZZLED RECEPTORS that may function as an inhibitor or activator of the WNT SIGNALING PATHWAY. For example, it activates signaling in the presence of Frizzled-4 but is inhibitory when coupled with ROR2 TYROSINE KINASE. It is required for axis formation during EMBRYOGENESIS and inhibits the proliferation, migration, and invasiveness of cancer cells.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
4 entry terms
- Wingless-Type MMTV Integration Site Family, Member 5A
- Wnt5a Protein
- Wingless Type MMTV Integration Site Family, Member 5A
- Wnt 5a Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Proto-Oncogene Proteins (1994-2016)
- Wnt Proteins (2006-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Wnt-5a Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071818. http://id.nlm.nih.gov/mesh/2026/D000071818
- Wnt-5a Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24777136