Diseases

Wolfram Syndrome

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • DIDMOAD
  • DIDMOAD Syndrome
  • DIDMOADUD
  • Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness
  • Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness
  • Syndrome, Wolfram
  • Wolfram Syndrome 1

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

86

MeSH Record

Previous Indexing

  • Deafness (1966-1985)
  • Diabetes Insipidus (1966-1985)
  • Diabetes Mellitus, Insulin-Dependent (1984-1985)
  • Optic Atrophy (1966-1985)

MeSH Hierarchy

Tree Numbers

  1. C09.218w.458.341w.186.500w.750w
  2. C10w.292w.700w.225.500.980w
  3. C10w.574w.500.662.980w
  4. C10w.597.751.418.341w.186.500w.750w
  5. C10w.597.751.941w.162w.625w.750w
  6. C11w.270.564.980w
  7. C11w.640w.451.451.980w
  8. C11w.966w.075w.375w.750w
  9. C12.050.351.968w.419w.135w.875w
  10. C12.200.777w.419w.135w.875w
  11. C12.950w.419w.135w.875w
  12. C16w.131w.077w.299w.750w
  13. C16w.320w.290.564.980w
  14. C16w.320w.400.630.980w
  15. C18.452w.394.750w.124w.960w
  16. C19w.246w.267w.960w
  17. C19w.700w.159w.875w

AMA Style

References

  1. National Library of Medicine. Wolfram Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D014929. http://id.nlm.nih.gov/mesh/2026/D014929
  2. Wolfram Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Wolfram_syndrome
  3. Wolfram Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1153641