Chemicals and Drugs

Wortmannin

An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential.

Chemical Identity

Chemical Information

Molecular Formula
C23H24O8
Molecular Weight
428.4 g/mol
CAS Registry No.
19545-26-7
IUPAC Name
[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
InChIKey
QDLHCMPXEPAAMD-QAIWCSMKSA-N
SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
MeSH Unique ID
D000077191
Source
PubChem CID 312145

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • MS 54
  • MS-54
  • MS54

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1974)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.054.079.129.891w

AMA Style

References

  1. National Library of Medicine. Wortmannin. Medical Subject Headings (MeSH). 2026. Unique ID D000077191. http://id.nlm.nih.gov/mesh/2026/D000077191
  2. Wortmannin. In: Wikipedia. https://en.wikipedia.org/wiki/Wortmannin
  3. Wortmannin. In: Wikidata. https://www.wikidata.org/wiki/Q73401372
  4. Wortmannin. In: PubChem Compound. CID 312145. https://pubchem.ncbi.nlm.nih.gov/compound/312145