Chemicals and Drugs

alpha Karyopherins

Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.

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See Also

MeSH Record

Synonyms

9 entry terms
  • Importin-alpha
  • Karyopherin alpha
  • NLS Receptor
  • NLS-Binding Protein
  • NLSBP
  • Nuclear Localization Sequence Receptor
  • Nuclear Localization Signal-Binding Protein
  • Karyopherins, alpha
  • receptor, NLS

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001

MeSH Record

Previous Indexing

  • Nuclear Proteins (1994-2001)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.750.500w.100
  2. D12.776w.543w.585w.750.500w.100
  3. D12.776w.660w.502w.100

AMA Style

References

  1. National Library of Medicine. alpha Karyopherins. Medical Subject Headings (MeSH). 2026. Unique ID D028901. http://id.nlm.nih.gov/mesh/2026/D028901
  2. alpha Karyopherins. In: Wikidata. https://www.wikidata.org/wiki/Q76849849