Chemicals and Drugs

c-Mer Tyrosine Kinase

A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • MERTK
  • c-Mer Proto-Oncogene Tyrosine Kinase
  • Kinase, c-Mer Tyrosine
  • Tyrosine Kinase, c-Mer
  • c Mer Proto Oncogene Tyrosine Kinase
  • c Mer Tyrosine Kinase

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins (1999-2017)
  • Receptor Protein-Tyrosine Kinases (1999-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.003
  2. D12.776w.476.568w.400w.003
  3. D12.776w.543w.750w.630w.003
  4. D12.776w.624.664.700.037

AMA Style

References

  1. National Library of Medicine. c-Mer Tyrosine Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D000076202. http://id.nlm.nih.gov/mesh/2026/D000076202
  2. c-Mer Tyrosine Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q21120828