Structured Summary
Abstract
Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.
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Synonyms
9 entry terms
- Genes, erbB
- erbB Gene
- c-erbB-3 Genes
- erbB-3 Genes
- Genes, c-erbB-3
- c erbB 3 Genes
- c-erbB-3 Gene
- erbB 3 Genes
- erbB-3 Gene
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
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Indexing Annotation
spell in titles & translations as erbB; GENES, ERBB-1 & GENES, ERBB-2 are also available
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History Note
95
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Previous Indexing
- Proto-Oncogenes (1992-1994)
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References
- National Library of Medicine. erbB Genes. Medical Subject Headings (MeSH). 2026. Unique ID D018815. http://id.nlm.nih.gov/mesh/2026/D018815
- erbB Genes. In: Wikidata. https://www.wikidata.org/wiki/Q71148372