Structured Summary
Abstract
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (ERB-B2 RECEPTOR TYROSINE KINASES), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
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Synonyms
23 entry terms
- Genes, HER-2
- Genes, HER2
- Genes, erbB-2
- Genes, erbb2
- Genes, neu
- c-erbB-2 Genes
- c-erbB-2 Proto-Oncogenes
- Gene, HER2
- Gene, erbb2
- HER-2 Gene
- HER-2 Genes
- HER2 Gene
- HER2 Genes
- c erbB 2 Genes
- c erbB 2 Proto Oncogenes
- c-erbB-2 Gene
- c-erbB-2 Proto-Oncogene
- erbB 2 Genes
- erbB-2 Gene
- erbb2 Gene
- erbb2 Genes
- neu Gene
- neu Genes
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
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Indexing Annotation
in titles & translations spell as erbB-2; GENES, ERBB-1 is also available
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History Note
1995
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Previous Indexing
- Oncogenes (1986-1994)
- Proto-Oncogenes (1986-1994)
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AMA Style
References
- National Library of Medicine. erbB-2 Genes. Medical Subject Headings (MeSH). 2026. Unique ID D018734. http://id.nlm.nih.gov/mesh/2026/D018734
- erbB-2 Genes. In: Wikidata. https://www.wikidata.org/wiki/Q14877486