Chemicals and Drugs

Erb-b2 Receptor Tyrosine Kinases

Cell surface receptor protein-tyrosine kinases receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell surface receptor protein-tyrosine kinases receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

36 entry terms
  • Antigens, CD340
  • CD340 Antigen
  • ERBB2 Receptor Tyrosine-protein Kinase
  • HER-2 Proto-Oncogene Protein
  • Metastatic Lymph Node Gene 19 Protein
  • Neu Receptor
  • Oncogene Protein HER-2
  • Proto-Oncogene Protein HER-2
  • Proto-Oncogene Protein p185(neu)
  • Proto-Oncogene Proteins c-erbB-2
  • Proto-oncogene Protein Neu
  • Receptor tyrosine-protein kinase erbB-2
  • Receptor, ErbB-2
  • Receptor, Neu
  • Receptors, erbB-2
  • Tyrosine Kinase-type Cell Surface Receptor HER2
  • c-erbB-2 Protein
  • erbB-2 Proto-Oncogene Protein
  • neu Proto-Oncogene Protein
  • p185(c-neu)
  • p185erbB2 Protein
  • CD340 Antigens
  • Erb b2 Receptor Tyrosine Kinases
  • ErbB-2 Receptor
  • HER 2 Proto Oncogene Protein
  • Oncogene Protein HER 2
  • Proto Oncogene Protein HER 2
  • Proto Oncogene Proteins c erbB 2
  • Proto-Oncogene Protein, HER-2
  • Proto-Oncogene Protein, erbB-2
  • Proto-Oncogene Protein, neu
  • Tyrosine Kinase type Cell Surface Receptor HER2
  • c erbB 2 Protein
  • erbB 2 Proto Oncogene Protein
  • erbB-2 Receptors
  • neu Proto Oncogene Protein

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2019 (1995)

MeSH Record

Previous Indexing

  • Epidermal Growth Factor Receptor Protein-Tyrosine Kinase (1994)
  • Phosphoproteins (1985)
  • Proto-Oncogene Proteins (1986-1994)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.009w.400w
  2. D12.776w.476.568w.400w.009w.400w
  3. D12.776w.543w.750w.630w.009w.400w
  4. D12.776w.543w.750w.750w.400w.074w.400w
  5. D12.776w.624.664.700.642w
  6. D23.050w.301.500.600w.700w
  7. D23.050w.705.552.600w.550w
  8. D23.101w.140.642w

AMA Style

References

  1. National Library of Medicine. Erb-b2 Receptor Tyrosine Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D018719. http://id.nlm.nih.gov/mesh/2026/D018719
  2. Erb-b2 Receptor Tyrosine Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/HER2
  3. Erb-b2 Receptor Tyrosine Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q415271