Chemicals and Drugs

trkA Receptor

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

23 entry terms
  • NTRK1 Receptor
  • Neurotrophic Tyrosine Kinase Receptor Type 1
  • Proto-Oncogene Products c-trk
  • Proto-Oncogene Protein trk
  • Receptor, Neurotrophic Tyrosine Kinase Type 1
  • Receptor, trkA
  • c-trk Protein
  • gp140 c-trk
  • gp140(c-TRK)
  • p140-trkA
  • trk Proto-Oncogene Protein
  • trk1 Transforming Tryrosine Kinase
  • Proto Oncogene Products c trk
  • Proto Oncogene Protein trk
  • Proto-Oncogene Protein, trk
  • Receptor, NTRK1
  • c trk Protein
  • c-trk, Proto-Oncogene Products
  • c-trk, gp140
  • gp140 c trk
  • p140 trkA
  • trk Proto Oncogene Protein
  • trk, Proto-Oncogene Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; use RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE(NM) 1990-1999

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins (1990-1999)
  • Receptor Protein-Tyrosine Kinases (1994-1999)
  • Receptors, Nerve Growth Factor (1994-1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.660
  2. D12.776w.476.568w.400w.660
  3. D12.776w.543w.750w.630w.496
  4. D12.776w.543w.750w.750w.400w.550w.550

AMA Style

References

  1. National Library of Medicine. trkA Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D020917. http://id.nlm.nih.gov/mesh/2026/D020917
  2. trkA Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24726467