Structured Summary
Abstract
The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.
Chemical Identity
Chemical Information
- Molecular Formula
- C17H16ClN3O
- Molecular Weight
- 313.8 g/mol
- CAS Registry No.
- 14028-44-5
- IUPAC Name
- 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
- InChIKey
- QWGDMFLQWFTERH-UHFFFAOYSA-N
- SMILES
- C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
- MeSH Unique ID
- D000657
- Source
- PubChem CID 2170
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
9 entry terms
- 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
- Desmethylloxapine
- Asendin
- Asendis
- CL-67,772
- Demolox
- Défanyl
- CL 67,772
- CL67,772
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(75); was see under DIBENZOXAZEPINES 1975-90
MeSH Record
Previous Indexing
- Dibenzoxazepines (1971-1974)
- Piperazines (1971-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Amoxapine. Medical Subject Headings (MeSH). 2026. Unique ID D000657. http://id.nlm.nih.gov/mesh/2026/D000657
- Amoxapine. In: Wikipedia. https://en.wikipedia.org/wiki/Amoxapine
- Amoxapine. In: Wikidata. https://www.wikidata.org/wiki/Q58356
- Amoxapine. In: PubChem Compound. CID 2170. https://pubchem.ncbi.nlm.nih.gov/compound/2170