Diseases

Autoimmune Lymphoproliferative Syndrome

Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.

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Classification

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Synonyms

24 entry terms
  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant
  • Canale Smith Syndrome
  • Canale-Smith Syndrome
  • Autoimmune Lymphoproliferative Syndromes
  • Canale-Smith Syndromes
  • Lymphoproliferative Syndrome, Autoimmune
  • Lymphoproliferative Syndromes, Autoimmune
  • Syndrome, Autoimmune Lymphoproliferative
  • Syndrome, Canale Smith
  • Syndrome, Canale-Smith
  • Syndromes, Autoimmune Lymphoproliferative
  • Syndromes, Canale-Smith
  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant
  • Autoimmune Lymphoproliferative Syndrome Type 2B
  • Autoimmune Lymphoproliferative Syndrome Type 2B (ALPS2B)
  • Autoimmune Lymphoproliferative Syndrome, Type IIb
  • Caspase 8 Deficiency
  • Caspase-8 Deficiency
  • Caspase 8 Deficiencies
  • Caspase-8 Deficiencies
  • Deficiencies, Caspase 8
  • Deficiencies, Caspase-8
  • Deficiency, Caspase 8
  • Deficiency, Caspase-8

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Autoimmune Diseases (1997-2009)
  • Lymphoproliferative Disorders (1983-2009)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Autoimmune Lymphoproliferative Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D056735. http://id.nlm.nih.gov/mesh/2026/D056735
  2. Autoimmune Lymphoproliferative Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Autoimmune_lymphoproliferative_syndrome
  3. Autoimmune Lymphoproliferative Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1151300