Structured Summary
Abstract
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
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Classification
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Synonyms
9 entry terms
- CAP4 Protease
- Caspase-8
- FLICE Protein
- MACH Protein
- Mch5 Protease
- Pro-Caspase-8
- Procaspase-8
- Pro Caspase 8
- Procaspase 8
MeSH Record
Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(2000)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Caspase 8. Medical Subject Headings (MeSH). 2026. Unique ID D053181. http://id.nlm.nih.gov/mesh/2026/D053181
- Caspase 8. In: Wikidata. https://www.wikidata.org/wiki/Q5049059