Chemicals and Drugs

CRADD Signaling Adaptor Protein

A death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Caspase and Rip Adaptor with Death Domain Protein
  • RAIDD Signaling Adaptor Protein
  • RIP-Associated Protein With a Death Domain
  • RIP Associated Protein With a Death Domain

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2005-2006)
  • Proteins (1997-2004)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.131.186
  2. D12.644w.360.024w.285.050
  3. D12.644w.360.024w.500w.050
  4. D12.644w.360.075.358.186
  5. D12.644w.360.075.421.050
  6. D12.776w.157w.057w.006.186
  7. D12.776w.157w.057w.018.050
  8. D12.776w.157w.057w.500w.050
  9. D12.776w.476.024w.139.186
  10. D12.776w.476.024w.320.050
  11. D12.776w.476.024w.500w.050
  12. D12.776w.476.075.358.186
  13. D12.776w.476.075.421.050

AMA Style

References

  1. National Library of Medicine. CRADD Signaling Adaptor Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053420. http://id.nlm.nih.gov/mesh/2026/D053420
  2. CRADD Signaling Adaptor Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21105410