Chemicals and Drugs

Chlorambucil

A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)

Chemical Identity

Chemical Information

Molecular Formula
C14H19Cl2NO2
Molecular Weight
304.2 g/mol
CAS Registry No.
305-03-3
IUPAC Name
4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
MeSH Unique ID
D002699
Source
PubChem CID 2708

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
  • Chloraminophene
  • Chlorbutin
  • N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
  • Amboclorin
  • CB-1348
  • Leukeran
  • Lympholysin
  • NSC-3088
  • CB 1348
  • CB1348
  • NSC 3088
  • NSC3088

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D02w.455w.526.728w.650w.156w

AMA Style

References

  1. National Library of Medicine. Chlorambucil. Medical Subject Headings (MeSH). 2026. Unique ID D002699. http://id.nlm.nih.gov/mesh/2026/D002699
  2. Chlorambucil. In: Wikipedia. https://en.wikipedia.org/wiki/Chlorambucil
  3. Chlorambucil. In: Wikidata. https://www.wikidata.org/wiki/Q415939
  4. Chlorambucil. In: PubChem Compound. CID 2708. https://pubchem.ncbi.nlm.nih.gov/compound/2708