Chemicals and Drugs

Prednimustine

Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.

Chemical Identity

Chemical Information

Molecular Formula
C35H45Cl2NO6
Molecular Weight
646.6 g/mol
CAS Registry No.
29069-24-7
IUPAC Name
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate
InChIKey
HFVNWDWLWUCIHC-GUPDPFMOSA-N
SMILES
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC(=O)CCCC4=CC=C(C=C4)N(CCCl)CCCl)O)CCC5=CC(=O)C=C[C@]35C)O
MeSH Unique ID
D011238
Source
PubChem CID 34457

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Leo-1031
  • NSC-134087
  • Sterecyt
  • Stereocyt
  • Stéréocyt
  • Leo 1031
  • Leo1031
  • NSC 134087
  • NSC134087

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(80); was see under CHLORAMBUCIL 1980-90

MeSH Record

Previous Indexing

  • Chlorambucil (1966-1974) /analogs & derivatives (1975-1979)
  • Prednisolone (1966-1974) /analogs & derivatives (1975-1979)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.526.728w.650w.156w.700w
  2. D04w.210.500w.745.432w.769.795w.700w

AMA Style

References

  1. National Library of Medicine. Prednimustine. Medical Subject Headings (MeSH). 2026. Unique ID D011238. http://id.nlm.nih.gov/mesh/2026/D011238
  2. Prednimustine. In: Wikipedia. https://en.wikipedia.org/wiki/Prednimustine
  3. Prednimustine. In: Wikidata. https://www.wikidata.org/wiki/Q7239694
  4. Prednimustine. In: PubChem Compound. CID 34457. https://pubchem.ncbi.nlm.nih.gov/compound/34457