Chemicals and Drugs

Class Ia Phosphatidylinositol 3-Kinase

A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

51 entry terms
  • Class Ia Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol 3-Kinase, Class Ia
  • Class Ia Phosphatidylinositol 3 Kinase
  • Class Ia Phosphatidylinositol 3 Kinases
  • Phosphatidylinositol 3 Kinase, Class Ia
  • Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit
  • Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit
  • Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide
  • Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide
  • Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide
  • Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide
  • Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide
  • Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide
  • Phosphoinositide-3-Kinase, Regulatory Subunit 1
  • Phosphoinositide-3-Kinase, Regulatory Subunit 2
  • Phosphoinositide-3-Kinase, Regulatory Subunit 3
  • alpha-P85 Subunit, PI-3K
  • p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
  • Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit
  • Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit
  • PI-3K alpha-P85 Subunit
  • Phosphoinositide 3 Kinase, Regulatory Subunit 1
  • Phosphoinositide 3 Kinase, Regulatory Subunit 2
  • Phosphoinositide 3 Kinase, Regulatory Subunit 3
  • p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
  • p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2011; for ALPHA-P85 SUBUNIT, PI-3K use PHOSPHATIDYLINOSITOL 3-KINASES 1998-2010

MeSH Record

Previous Indexing

  • Phosphatidylinositol 3-Kinases (1998-2010)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.500w.100.100w.100
  2. D08.811w.913w.696w.620.500w.200w.100w.100
  3. D12.776w.476.556w.100.100w.100
  4. D12.776w.476.556w.200w.100w.100

AMA Style

References

  1. National Library of Medicine. Class Ia Phosphatidylinositol 3-Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D058543. http://id.nlm.nih.gov/mesh/2026/D058543
  2. Class Ia Phosphatidylinositol 3-Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q78315624