Chemicals and Drugs

Diflucortolone

A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.

Chemical Identity

Chemical Information

Molecular Formula
C22H28F2O4
Molecular Weight
394.5 g/mol
CAS Registry No.
2607-06-9
IUPAC Name
(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
InChIKey
OGPWIDANBSLJPC-RFPWEZLHSA-N
SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C)F
MeSH Unique ID
D004060
Source
PubChem CID 11954369

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Ro 10-7614
  • Ro 10 7614
  • Ro 107614

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(80); was see under FLUOCORTOLONE 1980-90

MeSH Record

Previous Indexing

  • Fluocortolone/analogs & derivatives (1975-1979)
  • Glucocorticoids (1967)
  • Glucocorticoids, Topical (1973-1979)
  • Pregnadienediols (1974-1979)
  • Pregnadienes (1973)
  • Pregnanes (1968-1972)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.745.432w.719.320w.250w
  2. D04w.210.500w.908.405w.250w

AMA Style

References

  1. National Library of Medicine. Diflucortolone. Medical Subject Headings (MeSH). 2026. Unique ID D004060. http://id.nlm.nih.gov/mesh/2026/D004060
  2. Diflucortolone. In: Wikipedia. https://en.wikipedia.org/wiki/Diflucortolone
  3. Diflucortolone. In: Wikidata. https://www.wikidata.org/wiki/Q5275453
  4. Diflucortolone. In: PubChem Compound. CID 11954369. https://pubchem.ncbi.nlm.nih.gov/compound/11954369